Metformin Success Stories: Does Metformin Cause Weight Loss?

Metformin, a medication traditionally prescribed for type 2 diabetes, has gained popularity as an off-label weight loss aid in recent years (we’ve all heard about a few Metformin weight loss success stories here and there on the Net). Many patients approach me with questions about it and inquire if I’m aware of various success stories involving metformin and weight loss.

By lowering blood sugar levels through the reduction of glucose (sugar) produced by the liver, as well as by decreasing insulin levels and enhancing insulin sensitivity, Metformin serves both type 2 diabetes and PCOS patients. Research indicates that metformin may contribute to weight loss or the maintenance of weight loss, making it a sought-after option for shedding pounds, although it lacks FDA approval as an anti-obesity medication.

Glucophage is the brand name for metformin, available in pill and liquid formulations. Those who employ it to manage type 2 diabetes have discovered an added benefit of the drug—weight loss. While some studies lend support to this notion, the evidence is not definitive, prompting a need for further investigations.

If you’re utilizing metformin for weight loss without having type 2 diabetes or PCOS, its effects on your body mirror those in individuals with diabetes. It diminishes insulin resistance, promoting improved sugar metabolism.

Does Metformin Cause Weight Loss?

Metformin comes with a notable side effect: decreased appetite. This could actually be the key reason behind metformin’s success as a weight loss aid. When you’re on this medication, you might find yourself eating less without even realizing it.

However, it’s important to note that metformin does have some less-than-pleasant effects, such as diarrhea and stomach discomfort. Fortunately, these side effects are usually temporary and might even play a role in kickstarting some initial weight loss.

Rapid weight loss with metformin?

While research has indicated that metformin might assist in weight loss, it’s important to understand that it isn’t a rapid solution for addressing obesity. The weight reduction attributed to metformin generally unfolds gradually across several months to even years. The pace of this process varies from person to person and is influenced by other aspects like lifestyle, diet, and exercise.

From a medical standpoint, metformin’s official approval is solely for type 2 diabetes. Nonetheless, it’s worth noting that it’s sometimes utilized off-label as a means to aid weight loss and manage PCOS.

How to Reverse Insulin Resistance

Incorporating metformin when you have insulin resistance can significantly enhance the outcomes of your workouts. It not only boosts the calories you burn during exercise but also enhances insulin sensitivity. If you find yourself putting in considerable effort through exercise and diet, yet struggle to shed weight, insulin resistance might be the underlying issue.

When insulin resistance is present, muscles become unresponsive to insulin and fail to metabolize efficiently. As a result, muscles lack the necessary sugar-derived energy, leading to fatigue. Surprisingly, the calories you consume don’t adequately nourish your muscles; instead, they are stored in fat cells, particularly around the abdomen, due to rapid fat accumulation.

Insulin resistance is prevalent among individuals with excess weight or obesity. If your waistline measures above 40 inches for men or 35 inches for women, it’s quite likely that you’re already grappling with insulin resistance.

Insulin resistance tends to develop as people age. Consequently, maintaining a healthy weight becomes more challenging as you approach middle age. Over time, fat accumulates amidst the muscles, which contrasts with the lack of this issue among active young individuals.

Adults who become less physically active progressively accumulate greater amounts of unused fat. This gradual buildup can eventually lead to metabolic syndrome, further complicating the process of fat loss.

How to use Metformin for Weight Loss

Metformin isn’t an over-the-counter medication; it requires a prescription from your healthcare provider. Typically, it’s initiated at the lowest dosage to minimize potential side effects.

Before considering metformin as a weight loss aid, it’s crucial to establish a nutritious diet plan with guidance from your weight loss specialist. Metformin is known to decrease appetite, which can facilitate adherence to your diet plan. Nevertheless, maintaining adequate nutrient intake and staying hydrated remain essential.

Streamlining your shopping and prepping your meals can significantly simplify adhering to your diet plan. This approach minimizes the need for constant deliberation.

Like any medication, metformin comes with its set of side effects. Therefore, it’s imperative to engage in a thorough discussion with your doctor to weigh the advantages and disadvantages.

Metformin for Insulin Resistance Syndrome Reviews: Success Stories & Negative Experiences

With an average score of 7.4 out of 10 based on a cumulative total of 57 reviews, Metformin is commonly used off-label to address Insulin Resistance Syndrome. Among these reviews, 61% expressed a favorable experience, whereas 18% conveyed a less positive encounter.

Note: The source of all these reviews (that we rephrased without changing the user’s experience and rating) is Drugs.com (visit their site to check the users’ reviews in their own words).

Catniss’s Story with Metformin: Taken for 1 to 6 months || September 7, 2022

“I’ve been dealing with PCOS and a looming threat of cancer near my left ovary for a while. The specter of type II diabetes has lingered for 15 years, which is quite perplexing given my minimal sugar intake due to my numerous allergies. My doctor insisted on metformin. Things were going well for around 2 months… until I noticed clumps of hair falling out. It’s been a struggle to halt it, even though Spiro has offered some relief. While I did manage to shed 5 pounds, it hardly compensates for my hair loss. Since I’m not inclined towards medication, I’m reverting to the basics, embracing a regimen of various desiccated bovine organs like ovaries, liver, and kidneys. I’ve also incorporated a range of supplements, along with consuming raw liver exclusively sourced from the butcher. This approach has actually made me feel better.”

Anakar’s Story with Metformin: Taken for less than 1 month || June 3, 2023

“I gave this medication a shot for 13 days in early 2020 to address insulin resistance. Regrettably, my body didn’t agree with it. After taking just one 850 mg tablet, I experienced anxiety attacks and wrestled with insomnia every single night. It seemed to trigger my ovaries, possibly affecting my estrogen and progesterone levels, which wasn’t ideal considering my age (perimenopause). I decided to discontinue its use and turned to an alternative medication that ultimately managed to resolve the issue.”

Grate’s Story with Metformin || February 23, 2020

“Upon undergoing a 2-hour glucose test, I discovered that I had insulin resistance. My doctor recommended Glucophage, a prescription I was initially hesitant about. I’ve been grappling with intense anxiety and periodic bouts of depression. However, this medication brought about a transformative shift. The cloud of depression, anxiety, and mental haziness lifted. Astonishingly, I didn’t encounter any adverse effects. This truly became a turning point in my life. Despite years of seeking help from various psychiatrists, none managed to alleviate my anxiety. I’m elated to report that I’ve been cured. For the first time in 15 years, I am free from the grips of anxiety and depression.”

CoolM’s Story with Metformin || March 15, 2015

“A Game Changer! I took 500 mg once a day, combined with a low-carb diet (around 7 servings daily), starting at 375 lbs. Also, I stayed committed and saw remarkable results – shedding 60 lbs in 60 days. I incorporated an hour of daily cardio (Zumba), which I continued. Over the next 2 years, my weight loss reached an impressive 150 lbs.

Every side effect of metformin served as a clear signal: I was consuming excessive carbs. It’s almost illogical for a doctor to prescribe metformin without also recommending a low-carb diet. I’ve been astonished at the number of people I’ve talked to who’ve encountered this situation over the years. Diarrhea, nausea, a metallic taste – these symptoms actually indicate an improper diet. They’re not reasons to quit the medication; they’re evidence that a low-carb approach is necessary.

Fast forward 7 years, and I’ve still maintained a weight loss of 100 lbs. I’m even considering increasing the dose to keep up the momentum of my weight loss journey.”

QueenQ’s Story with Metformin || September 12, 2019

“Experiencing a surge of energy, my skin, hair, and nails have taken on a flawless quality. My mood has undergone a remarkable uplift, making me feel more attractive and even somewhat alluring. I’ve been turning heads at traffic lights – it’s quite amusing! Remarkably, my cravings for sweets have diminished, and those late-night hunger pangs are nowhere to be found. I’m consuming just half of my usual portions, feeling amply satisfied after a few bites. No headaches or dizziness to report, just a slight feeling of stomach comfort. Interestingly, I’ve developed a consistent thirst, which is beneficial as I’m now drinking 1.5 liters of water, a significant increase from my previous 500 ml. The bloated look in my belly has notably reduced. Metformin, you’ve earned my affection <3.”

Jill’s Story with Metformin: Taken for less than 1 month || November 9, 2020

“I’ve been using metformin for 5 days now to tackle insulin resistance, and remarkably, I haven’t encountered any side effects thus far. Strangely enough, my emotional state has taken an incredibly positive turn – could this be a mood booster? I remember my experience with SSRIs, and they never matched up to this level of well-being. Honestly, my mood has been overwhelmingly good, and the anxiety that used to nag me is nowhere to be found.”

Vrh’s Story with Metformin: Taken for less than 1 month || March 14, 2021

“I’ve recently started taking this medication. Currently, my daily intake consists of 1000 mg of IR. Surprisingly, I haven’t experienced any of those unsettling side effects that others have often talked about. There have been occasional, mild stomach cramps and brief moments of nausea that don’t exceed around 10 minutes per day. Interestingly, my appetite has notably decreased. On top of that, I’ve observed a reduction in mood swings, which is a welcomed change. I’m genuinely optimistic that this might assist in my weight loss journey! I’ll provide an update on my progress within the next month or two.”

Dani’s Story with Metformin || Taken for 1 to 6 months || June 4, 2020

“Hello, I’d like to share my journey. I’m dealing with a mental illness, and the medications I’m on led to a slight weight gain. I was unwilling to alter my mental health treatment for fear of a setback. Long story short, I was prescribed metformin a few months ago. At that time, I weighed 98.2kg, and now I’m down to 93.5kg. I’m genuinely pleased about shedding the weight. I’ve made a conscious effort to reduce my intake of unhealthy foods and introduced more fruits and salads into my diet. Additionally, metformin has been a boon in terms of curbing my nighttime cravings. I’m hopeful to achieve further progress, but only time will reveal the complete outcome.”

Steve’s Story with Metformin || September 6, 2014

“My husband’s journey took a turn when he received a diagnosis of Metabolic Syndrome. The Endocrinologist, after months of misdiagnosis by our GP and grappling with exhaustion and depression, prescribed him four daily doses of metformin. This came after a period of believing he had hypothyroidism. His belly fat had piled up, and at 5 feet 3 inches, weighing 207 lbs was not ideal.

In just one month of being on metformin, coupled with a conscious reduction of carbs in his diet, he managed to shed an impressive 20 lbs. The transformation in his well-being is undeniable. His energy levels have soared, and the weight continues to melt away from his belly. Opting to consult the Endocrinologist was indeed a wise choice; their accuracy was remarkable. In a few months, I’m confident I’ll see my svelte husband return.”

Ashly’s Story with Metformin || March 30, 2015

“It’s been around a month and a half since I started taking Metformin, and surprisingly, I’ve managed to shed about 12lbs. This is rather exciting, considering my previous attempts with calorie counting and various diets never yielded such results. I do experience stomach cramps, occasional bouts of diarrhea, and dizziness, though they aren’t too bothersome. My dosage is 500mg twice a day. What’s truly remarkable to me is how this medication has positively impacted me. I’m feeling quite well, my energy levels are up, and those constant cravings for sweets and caffeine have subsided. All in all, I’m thoroughly impressed by the effects and would give it a perfect ten.”

Hannah’s Story with Metformin || January 9, 2017

“When I initially began using this medication, it was a tough ride. I experienced severe fatigue, stomach cramps, irregular bowel movements, and even went through instances of vomiting blood. Despite enduring all of this, I opted to lower my dosage while remaining on the medication, and the outcome has been remarkable. After approximately three weeks of this ordeal, I started regaining a sense of normalcy and noticed a drop in weight. I’ve managed to shed 25lbs in total, purely by sticking to a healthy diet. It curbs my appetite, though not to an extent that causes any harm. I’m currently taking 500mg twice daily. It’s worth giving the medication a chance, as many individuals require a few months for it to fully take effect.”

Aonghus’ Story with Metformin: Taken for 1 to 6 months || May 27, 2020

“For the past two decades, I’ve been grappling with low testosterone, high blood pressure, and excess weight (reaching 291lbs). My journey with Metformin began in mid-January, and I gradually increased my dosage to 2000mg daily. Fast forward to today (May 27, 2020), and I’m elated to share that I’ve shed a remarkable 53 pounds. The medication has also slashed my appetite by more than half. Interestingly, my blood pressure is gradually decreasing to the extent that my medication needs to be adjusted.

The joy of mountain biking has returned to my life, and overall, I’m experiencing a fantastic state of well-being. Despite encountering some minor side effects, they haven’t been a significant hindrance. It’s becoming evident that most of my challenges trace back to insulin resistance. I recommend embarking on your own research and having a conversation with your doctor. I’ve found through my online exploration that achieving such a substantial weight loss is quite uncommon.”

Texxan’s Story with Metformin || April 1, 2012

“My journey with Metformin started under the guidance of my endocrinologist, who identified metabolic syndrome as my diagnosis. Initially referred by my primary care physician due to concerns about prediabetes, my triglyceride levels were alarmingly high, peaking at a staggering 3500!

Before incorporating Metformin, I had already taken steps to enhance my diet, focusing on caloric intake and the quality of foods I consumed. This effort yielded modest weight loss. However, once Metformin entered the picture, my triglycerides plummeted by an astonishing 90% – from 3500 to a mere 350. Alongside this improvement, the pounds began to melt away at a consistent pace. Over a span of approximately four months, I’ve managed to shed a remarkable 42 pounds, bringing me from 220 to 178 pounds.

Remarkably, this progress has been achieved despite my ongoing battle with alcohol consumption, averaging 7 to 10 beers each night, amounting to 99 calories per beer and a nightly total of 750 to 1000 calories.”

Lilly’s Story with Metformin: Taken for less than 1 month || January 26, 2014

“My experience with Glucophage (metformin) has spanned 2 1/2 weeks, aimed at managing Insulin Resistance due to Polycystic Ovarian Syndrome. Initially, I encountered a bit of nausea and diarrhea during the first two days. However, by the time day three or four rolled around, these negative side effects had already faded away. Interestingly, the impact of the medication was swift – I noticed rapid weight loss and a return to regular menstruation. Notably, within the first week, I observed an improvement in my skin’s condition.

The benefits of Glucophage extend to addressing several distressing aspects of PCOS. While I need more time to thoroughly evaluate the medication’s effectiveness, the initial results feel almost miraculous. Importantly, when taken with food, the side effects seem to be quite negligible.”

Chrissy’s Story with Metformin: Taken for less than 1 month || March 13, 2020

“Alright, I find myself in the prediabetic zone, and currently, I’m on Day 4 of metformin. Things are looking up so far. There’s been a noticeable boost in my energy levels, and I’ve experienced a subtle decrease in my appetite. I’m optimistic that this trend will continue; after all, I’m aiming to shed some pounds. My struggle used to be dealing with insulin spikes throughout the day, leading to hunger and an undeniable craving for starchy foods, especially in the latter part of my day. This made sticking to my diet quite a challenge. Thankfully, with metformin, the frequency of thoughts about food seems to have lessened. It’s as if I’m becoming more mindful about what I consume.”

Kell-E’s Story with Metformin: Taken for less than 1 month || February 26, 2023

“After avoiding doctor visits for several years, I noticed a gradual weight gain over a decade, despite my relatively healthy eating habits. I attributed it to a mix of menopause and stress. Eventually, I sought medical attention due to ongoing anxiety issues. My primary care physician conducted tests and the results were revealing. I was labeled as “obese,” my A1C measured at 6.4, and my glucose levels stood at 100 (taken right after a meal). In response, I was prescribed a 500mg dose to be taken with dinner.

Surprisingly, my dietary habits remained unchanged – I was already following a fairly healthy eating routine. However, I experienced an unexpected shift. Within 10 days, I lost 10 pounds! Admittedly, I did experience some light-headedness during the initial nights and encountered loose stools around the third day. Yet, aside from these minor inconveniences, I’ve been feeling quite good. I plan to provide an update following my next A1C checkup in May.”

Berq’s Story with Metformin: Taken for 1 to 6 months || March 3, 2019

“I’ve been using metformin for about a month now. Initially, I experienced a troublesome headache during the first two days, but that soon passed. When I began this journey, I weighed 102kg, and now I’m down to 94kg. However, it’s important to note that my transformation coincided with major lifestyle adjustments. Upon being diagnosed with insulin resistance, I made the decision to cut out alcohol, sugar, and lactose from my diet. Additionally, I intensified my workout routine. As per my endocrinologist’s advice, I’ve also incorporated vitamin D and B12 supplements into my regimen, which likely contributed to my progress. The remarkable aspect is that I haven’t encountered any side effects. My overall well-being has improved to an extent that I’ve never experienced before – a sense of happiness and vitality that I cherish.”

Vjm’s Story with Metformin || July 28, 2013

Tdl’s Story with Metformin || August 3, 2011

“For a span of five years, I’ve remained consistent with this medication. While it has effectively reduced my insulin levels, they have yet to reach the normal range. On a positive note, I’ve managed to shed an impressive 75 pounds, and my menstrual cycles have returned to their regular pattern. There was a period where I went nearly a year without any menstrual cycle at all. In addition to my insulin-related challenges, I also grapple with hypothyroidism. I believe that the favorable outcomes I’ve experienced can be attributed to this combination. My daily routine includes taking two 500mg pills, twice a day. It’s crucial for me to consume these pills with a meal; otherwise, I’m at risk of feeling unwell.”

Sheerla’s Story with Metformin || May 15, 2009

“Metformin has brought about significant improvements by effectively managing my insulin resistance. Initially, I encountered side effects like gas, diarrhea, and even some unpleasant breath odor, but thankfully, those have subsided over time. I wholeheartedly suggest Metformin to anyone dealing with sugar-related issues!”

JP35’s Story with Metformin: Taken for 6 months to 1 year || June 17, 2017

“I’m typically quite careful when it comes to trying out new medications. However, around half a year ago, I cautiously began taking metformin to address my impaired glucose tolerance – the best part is, it doesn’t cost me anything at my local drugstore. The difference it’s made in my well-being is truly remarkable! Notably, metformin played a role in curbing my appetite, which in turn motivated me to adopt a much healthier eating regimen. As a result, I’ve managed to shed 15 pounds. Though it’s essential to acknowledge that this transformation is a result of a combination of factors – metformin, healthier food choices, and increased physical activity. Another positive change I’ve observed is a reduction in the frequency of my migraine headache episodes, which used to be quite bothersome. This shift, too, can be attributed to a combination of medications and adopting healthier lifestyle practices.”

Anahe’s Story with Metformin || November 2, 2013

“According to popular belief, metformin has this interesting effect of making you more fertile. Surprisingly, I’ve experienced something similar. My hormones went a bit haywire for about a week, but things have settled down now, and I’m feeling pretty good. I’ve been gradually increasing my dosage, taking it slow and steady. I began with just one 500mg pill a day for a week, then added another 500mg for another seven days, and so on, until I reached a total of four pills per day.

What I found intriguing was that, even without using any lantus, my blood sugar readings were noticeably lower. However, they still weren’t quite low enough for me to consider discontinuing the lantus altogether. Interestingly, I realized that when relying solely on lantus, my overall mood wasn’t all that upbeat. But since starting metformin, my emotional state has taken a remarkable turn for the better. My moods have improved significantly, and I’ve become a noticeably happier individual.

While the short bout of diarrhea was a passing phase, it did make a brief reappearance when I bumped up the dosage. Now, though, I’ve grown accustomed to the pills, and my bowel movements have returned to their regular pattern.”

SashaQ’s Story with Metformin: Taken for less than 1 month || January 31, 2016

“Approximately three weeks ago, I embarked on a daily regimen of 1000 mg of Metformin. I split this dose, taking 500 mg during breakfast and another 500 mg with dinner. Almost immediately, I noticed a surge in mental clarity and energy, and I’ve even begun to see a modest reduction in weight. In the initial two weeks, I enjoyed the pleasant absence of any adverse symptoms – a truly delightful experience! However, as the medication becomes more integrated into my system, I’ve encountered bouts of intense nausea and dizziness. To manage these episodes, I’ve turned to large quantities of water and protein, which seems to provide some relief. Fortunately, these episodes tend to subside within an hour or so. I’m optimistic that these side effects will eventually fade as my body fully adjusts. Despite these occasional challenges, I remain deeply appreciative of the positive impact Metformin has had on me!”

FishNet’s Story with Metformin: Taken for 1 to 6 months || November 11, 2016

“Around five weeks ago, my doctor prescribed me Metformin, a dose of 500 mg taken twice daily, to address my insulin resistance. Over the course of a single month, I’ve managed to shed 15 pounds (though I still have a significant 85 pounds to go). Notably, I’ve experienced a surge in energy that’s allowed me to engage in more active daily routines and even incorporate exercise – a notable shift considering I used to be constantly plagued by pain and fatigue.

It’s important to mention that I’ve adopted a rigorous dietary regimen, strictly avoiding carbs and keeping my fat and calorie intake low. Consequently, while Metformin may be a contributing factor, I can’t definitively attribute all my progress to it. Admittedly, this marks my first encounter with medications for Type II diabetes, so I lack a basis for comparison with alternatives like Invokana. Regardless, I find myself quite satisfied with Metformin’s effects. It’s crucial to recognize that this isn’t a magical solution for weight loss; along with the medication, I’ve had to make significant changes in my eating patterns and activity levels.”

Nodoc’s Story with Metformin: Taken for less than 1 month || July 26, 2020

“After experiencing a miscarriage, I noticed a rapid weight gain of 5 to 7kg within a matter of days. Despite extreme dieting and exercise, my efforts only resulted in a slight 1 or 2 kg decrease after several weeks, followed by another sudden 5 to 7kg increase. This cycle continued, causing me to gradually gain more weight. Medical professionals consistently advised diet and exercise, yet I also battled symptoms such as a hard stomach, persistent bloating, and swelling in my hands and feet – to the extent that I couldn’t even wear shoes comfortably. Eventually, I was prescribed Metformin.

Interestingly, even though I didn’t significantly alter my diet or exercise routine, I managed to shed 4.4kg within just 12 days of starting Metformin. I’ve been informed that my miscarriage may have triggered an insulin spike. It’s worth noting that I am overweight and had previously lost more than 60kg through a slow and steady process, though it felt like an uphill struggle with minimal rewards. I’d like to emphasize that I’m not diabetic; my blood sugar levels remain within the normal range. These circumstances are quite perplexing. Do you have any insights or thoughts on this matter?”

Glasgow’s Story with Metformin: Taken for 10 years or more || April 26, 2015

“I had been on anti-depressants for more than 25 years. I had resigned myself to this when I received a diagnosis of insulin resistance. A compassionate doctor recommended a daily dose of 1,500mg of Metformin. Surprisingly, this led to significant alleviation of my symptoms, which were later found to be connected to Hereditary Hemochromatosis. All of this at the age of 66.”

Ren’s Story with Metformin || October 6, 2019

I’ve been on the maximum dose of Metformin for nearly two years now, even though I’m not diabetic and fall within a “normal” BMI range as a young woman. My endocrinologist diagnosed me with “prediabetes,” and I’ve remained below the diabetes threshold while taking Metformin. Adjusting to this medication was a bit challenging; I recall the initial weeks were marked by strong cramps, nausea, gas, loose stools, and even back pain. While the loose stools persist, the other symptoms have mostly eased. Despite these less-than-desirable side effects, Metformin has greatly assisted in stabilizing my weight (which was inexplicably increasing) and reducing my cravings. I’m considering discussing a dosage reduction with my doctor because I’ve noticed that it’s starting to affect my tolerance to alcohol and certain other medications.

More Reviews From Metformin Users (Source: Drugs.com)

Metformin Stories of Brand. & 2 Anonymous Users

Metformin Weight Loss Success Stories of Jul1e & Danie.

Metformin Weight Loss Success Stories of Jayless & Mali

Metformin Weight Loss Success Stories of Micheal. & Anonymous

Metformin Stories of Wilson. & Sadaf.

Metformin Stories of Dawn & Mimi

Metformin Stories of Gina & Maggie

Metformin Stories of Beth & Flicka

Metformin Weight Loss Success Stories of Tiarra, Arnsu. & BBBH

Metformin Stories of Not., Beth & Tigerkc

Metformin Stories of Jillyn & SIRS

Metformin Weight Loss Success Stories of Donna & YoUo

Metformin Stories of Nanel & Cary

Metformin Weight Loss Success Stories of Majeva & Trizzy

Metformin Stories of Petal, I. & Sweet.

Please note: The preceding content is for informational purposes only. Results will vary from one individual to another. You may try Metformin at your own risk. Please, always consult your doctor before starting any kind of treatment.

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